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Best Ergonomic Mouse (2022): Top Ergonomic Mice For Gaming, Productivity and More

Whether you are gaming or working, a mouse with a good ergonomic design will help prevent pain in your wrist and hands. A lot of people are required to spend most of their time in front of a computer with a mouse in hand, and taking steps to make sure that you are not damaging your wrist will go a long way. Here are our top picks for the best ergonomic mice.

Best Ergonomic Mouse Comparison Chart

ModelPriceCategoryStandout Features
Logitech MX VerticalCheck PriceBest ergonomic vertical mouseExcellent ergonomics, Wireless, Long battery life, Programmable shortcut buttons, Bluetooth
Logitech MX Master 3Check PriceBest ergonomic mouse for productivityWireless, Thumb wheel, Above average battery life, Bluetooth
Razer Basilisk UltimateCheck PriceBest ergonomic gaming mouse11 programmable buttons, Wireless, Thumb rest, Focus+ 20K sensor
Logitech Ergo M575Check PriceBest ergonomic trackball mouseStationary, Wireless, Bluetooth, Can be used on any surface
Anker 2.4G Wireless Vertical MouseCheck PriceBest budget ergonomic mouseCheap, Power saving mode

Logitech MX Vertical

Best ergonomic vertical mouse

best ergonomic mouse logitech mx vertical
One of the benefits of a vertical mouse, such as the Logitech MX Vertical, is less muscle strain due to how your hand is positioned.

When it comes to ergonomic mice, nothing beats a vertical mouse. A vertical mouse prevents muscle strain, pain and numbness by allowing your hand to be in a natural handshake position. It can even ease and prevent carpal tunnel syndrome and other similar conditions. As such, our pick for the best ergonomic mouse is the Logitech MX Vertical.

The Logitech MX Vertical is a feature-rich vertical mouse with a solid build and comfortable grip. It has a textured surface for additional grip, and its shape is compact enough that even people with smaller hands can use it. That said, this mouse is best suited for people with medium to large hands. If you have small hands, the Logitech Lift might be the better option for you.

It is a wireless mouse that also has Bluetooth connectivity, so it’s versatile in that regard. The built-in battery can last up to four months on a full charge, which is excellent. It sports a 4000 DPI sensor that’s good enough for a lot of people, and can even be used for some light gaming. Overall, if comfort is your number one requirement in a mouse, the Logitech MX Vertical is the best option available.

Logitech MX Master 3

Best ergonomic mouse for productivity

best ergonomic mouse logitech mx master 3
Aside from an ergonomic shape, the Logitech MX Master 3 also has a lot of productivity features such as gesture support and a thumb wheel.

If you don’t like the shape or feel of a vertical mouse, the MX Master 3 is a standard mouse with an ergonomic shape. It also has more productivity-geared features than the MX Vertical above. For productivity, this mouse is our best pick.

The Logitech MX Master 3 has an excellent build with a soft texture that’s feels nice. With a fairly large thumb rest on the left side, it’s designed for right-handed users. The mouse is a bit bulky as well, so it’s best for people with medium to large size hands. As for productivity features, it comes with MagSpeed wheel for more efficient and silent scrolling, it also has a thumb wheel for horizontal scrolling, and it supports mouse gestures.

Similar to the MX Vertical, the MX Master 3 is a wireless mouse that also comes with Bluetooth connectivity. You can connect the mouse to up to three machines simultaneously. The built-in battery lasts up to 70 days.

Razer Basilisk Ultimate

Best ergonomic gaming mouse

best ergonomic mouse razer basilisk ultimate
The Razer Basilisk Ultimate has excellent gaming performance and an ergonomic shape for those extended gaming sessions.

For gamers that value ergonomics more than gaming features, you can always go with a vertical mouse. However, if you can’t live without the gaming features of a gaming mouse, the Razer Basilisk Ultimate is the best option for you. Out of all the gaming mice in the market, the Basilisk Ultimate has the most ergonomic shape that can prevent hand and wrist strain.

The Razer Basilisk Ultimate is a wireless mouse that can rival even the best wired gaming mice in performance. It sports Razer’s Focus+ 20K sensor, and the HyperSpeed wireless technology from the company allows it to have a lower click latency for excellent gaming performance. As for its ergonomics, it has a shape that’s comfortable to grip and supports your wrist and hand. It also has a thumb rest on the left side for even more support.

Logitech Ergo M575

Best ergonomic trackball mouse

best ergonomic mouse logitech ergo m575
The Logitech Ergo M575 prevents hand and wrist strain since it is a stationary trackball mouse.

With a trackball, you don’t have to move your hand as much as when you are using a standard or vertical mouse, resulting in less strain on your hands and wrist. You only have to use your thumb and you don’t even have to grip the mouse to prevent repetitive strain injuries. In this category, our top pick is the Logitech Ergo M575.

The Logitech Ergo M575 is a wireless trackball that offers both 2.4GHz and Bluetooth connectivity, so you can connect it to multiple devices. It doesn’t need a lot of space as most mice do, so you can use it anywhere and on any surface. The Logitech Ergo M575 trackball offers precise tracking and it’s also removable for easy cleaning. One downside is that it doesn’t have a built-in battery, and it requires a single AA battery. On the upside, the battery can last up to 24 months.

Anker 2.4G Wireless Vertical Mouse

Best budget ergonomic mouse

best ergonomic mouse anker 2.4g wireless vertical mouse
The Anker 2.4G Wireless Vertical Mouse has an ergonomic shape, but it is best for people with medium to large hands.

As mentioned earlier, a vertical mouse is the best when it comes to ergonomics, so if you are looking for the best budget ergonomic mouse, our recommendation is the Anker 2.4G Wireless Vertical Mouse. It’s a vertical mouse that doesn’t come with all the bells and whistles, but it is affordable, and if budget is your main concern, this is the best pick.

It has all the buttons that you’ll need in a mouse, including the back and forward buttons on the side. There’s also a DPI switch with options for 800, 1,200 and 1,600 DPI tracking. As it is a budget option, there’s no built-in battery here. It runs on two AA batteries and it has power saving features that cuts off the power when the mouse is inactive for eight minutes. There’s nothing special about the Anker 2.4G wireless vertical mouse, but it offers all the functionalities that you’ll need in an affordable package.


The Logitech MX Vertical and the Logitech MX Master 3 are the best ergonomic mice.

Logitech MX Vertical

Best ergonomic vertical mouse

Logitech MX Master 3

Best ergonomic mouse for productivity

To summarize, the Logitech MX Vertical is our pick as the best ergonomic mouse. It’s a vertical mouse that allows your hand to be in a handshake position, which helps reduce strain and prevent discomfort as well as serious conditions such as carpal tunnel syndrome. The Logitech MX Vertical has the best ergonomics out of all the mice in this list.

However, if you want a standard mouse shape, the Logitech MX Master 3 is an excellent alternative and it has more productivity features. For gamers, the Razer Basilisk Ultimate is our recommendation since it provides support to your thumb, wrist and hand. If you prefer a trackball, the Logitech Ergo M575 is the best value pick, and for those that are on a budget, the Anker 2.4G Wireless Vertical is the best option.


๐Ÿ“Œ What’s best ergonomic mouse for carpal tunnel syndrome?

A good vertical mouse such as the Logitech MX Vertical is the best ergonomic mouse to prevent and/or alleviate carpal tunnel syndrome.

๐Ÿ“Œ What type of mouse is most ergonomic?

Vertical mice are the most ergonomic, but a slightly angled mouse that positions your hand in a slightly upright position, such as the Logitech MX Master 3, is great as well.

๐Ÿ“Œ What’s best ergonomic mouse for small hands?

The Logitech Lift is the best ergonomic vertical mouse that we can recommend. You can read our Lift vs MX Vertical comparison here.

๐Ÿ“Œ Are trackballs ergonomic?

Yes, trackballs can prevent a lot of hand/wrist/arm conditions by minimizing movement.

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Carlo Salvador

Senior Editor at Compare Before Buying. Writer and researcher passionate about fitness, gaming and music.